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<title>Simvastatin Side Effects</title>
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<description>Simvastatin Side Effects & History of Statins</description>
<pubDate>Thu, 01 Mar 2012 00:11:07 +0000</pubDate>
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<wp:author><wp:author_id>1</wp:author_id><wp:author_login>adm</wp:author_login><wp:author_email>kuroyan@dizero.com</wp:author_email><wp:author_display_name><![CDATA[adm]]></wp:author_display_name><wp:author_first_name><![CDATA[]]></wp:author_first_name><wp:author_last_name><![CDATA[]]></wp:author_last_name></wp:author>
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<title>Research Proves That Statins Reduce Risk of Colon Cancer: Simvastatin, Pravastatin Used</title>
<link>http://statinseffects.org/simvastatin-side-effects/?page_id=86</link>
<pubDate>Thu, 26 May 2011 07:28:57 +0000</pubDate>
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<content:encoded><![CDATA[In a demonstration, experimental study of more than four thousand patients living in northern part of Israel, use of statin consistently for a period of five years decreased by forty six percent the risk of colorectral cancer after correction for protective factors including use of non-steroidal anti-inflammatory drugs and aspirin. (Drug information about aspirin). The effects observed are not the consequence of decrease in cholesterol levels. The researchers from MECC – Molecular Epidemiology of Colorectal Cancer study group have admonished that it impulsive to alter either the indications of statins of proper care of colorectal cancer. It is suggested that statins have to be investigated further to find out the right cause.
Jenny N. Poynter, MPH, who belongs to Michigan University, has provided the results of the research at the 40<sup>th</sup> Annual conference of Society of Clinical Oncology representing the MECC group. Stephen B Gruber, M.D, PhD, MPH leads the MECC group who is the director of clinical cancer genetics at Michigan University Comprehensive Cancer Center along with Gadi Rennert, MD who is the director of National cancer control center for Israel’s largest HMO – Clalit Health Services.
The MECC research begin in 1999 with a grant of 4.8 million dollars from the National cancer Institute and extra funds received from Ravitz and Irving Weinstein foundations, which analyzes about how exercise, diet, genes and other factors combine to cause colon cancer. The descendants of Ashkenazi Jews have abnormally high rates of colon cancer along with novel cancer susceptibility allele, APC I1307K which is recognized in six percent and appears to increase the risk of colorectal cancer by twofold.
The researchers considered that the study of an Israeli based population along with ethnic group and Arab patients as well as Jews of non-Ashkenazi ethnicity might offer useful data regarding possible non-genetic factors which result in the formation of this disease. Statins were evaluated in this population, Ms. Poynter stated since they slowdown HMG CoA reductase that is present in excess quality in colorectal cancer cells and result in programmed cell death at physiologically pertinent conditions. The statins usage has also proved to minimize the formation of tumor when tested in animal’s cells.
Qualified patients were the people who were diagnosed with rectal or colon cancer between the years 1998-2004 (Total of 1814 cases). The controls were matched to cases based on sex, age and ethnicity (Jewish Vs Non-Jewish). The investigators also conducted matched analyzes on thousand five hundred and seventy perfectly matched case control pairs.
Use of medications and statins were analyzed by having personal interviews with each patient. The people who were using statin for minimum time span of five years were classified as “statin users” and non-users did not use statin at all. Regular use of statins as per prescriptions which suggested more than 3 times every year, was validated based on information from Clalit Health System database for most of the patients who reported statin usage. All the health problems were confirmed by a single pathologist who worked at University of Michigan.
Three hundred and twenty eight patients reported the use of statins for minimum five years; 222 controls and 106 cases. In an unmatched, unadjusted analysis, the protective impact of statins was observed with an Odds ratio of 0.49 and ninety five percent confidence level from 0.38 to 0.62 and highly significant P value [P < .0001]. Also, Ms. Poynter notified that similar results were observed in matched analysis of currently available 1, 570 pairs.
Simvastatin and Pravachol (Pravastatin) were the 2 forms of statins that was commonly used which accounted for fifty two percent and forty four percent of use, respectively. Both drugs were related with an associated risk of colorectal cancer (0.47 for simvastatin and 0.45 for prava-statin). The only other drug which lowers cholesterol and was used in this study is the fibric acid derivative (Bezalip) that has distinct pharmalogical activity when comopared to statins and reduces cholesterol by enhancing the functionality of lipoprotein lipase. Thirty nine patients indicated the use of bezafibrate for a period of five years. There was no clear relation between incidence of colorectal cancer and bezafibrate usage. The protective impact of statins is not especially due to general impact of reducing cholesterol and is associated with particular class of drugs as per Ms. Poynter.
After adjustments for possible confounders which include NSAIDs and Aspirin for a time period of five years, Ashkenazi ethnicity family history of colorectal cancer in a 1<sup>st</sup> degree relative along with participation in vegetable consumption, hypercholesterolemia, and sports activity in a matched analysis based on restricted logistic regression, the odds ratio was found to 0.54 for usage of statins and for a forty six percent reduction in colorectal cancer risk. It states that the defensive relation which was observed between colorectal cancer and statins is not suggested by other factors.
When the data was analyzed for rectal and colon cancer, noticeable protective effects was observed in both cancers (Odds Ratio was 0.38 for rectal cancer and 0.53 for colon cancer). Dr. Gruber stated at an ASCO press conference that “The data was very useful for future clinical trials. It is clear that use of statins can reduce the risk of colon cancer and the further investigation on this topic is absolutely necessary”.]]></content:encoded>
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<wp:meta_value><![CDATA[Research Proves That Statins Reduce Risk of Colon Cancer: Simvastatin, Pravastatin Used]]></wp:meta_value>
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<wp:meta_value><![CDATA[In a demonstration, experimental study of more than four thousand patients living in northern part of Israel, use of statin consistently for a period of five years decreased by forty six percent the risk of colorectral cancer.]]></wp:meta_value>
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<wp:comment_date_gmt>2011-08-04 15:08:42</wp:comment_date_gmt>
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